Association between prenatal phthalate exposure and anthropometric measures of newborns in a sample of Iranian population

Phthalates or phthalic acid esters (PAEs) are a group of compounds which they can be entered into the human body through various pathways. The aim this study was to examine associations between prenatal phthalates exposure with anthropometric measures neonates. Urine samples were obtained from 121 Iranian pregnant women at their first trimester pregnancy, and levels monobutyl phthalate (MBP), mono-benzyl (MBzP), mono-2-ethylhexyl (MEHP), mono (2-ethyl-5hydroxyhexyl) (MEHHP) metabolites determined by gas chromatography mass spectrometry (GC/MS). correlations maternal urinary concentrations neonates as well socio-demographic factors participants (maternal education, age, family income, pre-pregnancy index), lifestyle variables (smoking habit, food pattern, physical activity), use cleaning products (cosmetic household products) investigated. MBzP, MBP, MEHP, MEHHP detected in 100% concentration ranged 120 860 μg/g creatinine. Significant observed MBzP (adjusted β = 0.3 (0.001), p 0.03) 0.04) birth weight female MBP -0.3 (0.02), 0.02) had negative head circumference male newborns, respectively. Furthermore, plastic packaging for pickle passive smoking during pregnancy identified significantly associated low (p value < 0.05). higher compared other countries. Based on findings, could adversely impact health status newborns.